beneath such problems, observed substitutions amongst genomes approximate a random sample of the mutations which have occurred. Because of this, when assortment is comfortable, biases within the designs of substitutions noticed among genomes will improved approximate mutational biases. For this gui

beneath these conditions, observed substitutions between genomes approximate a random sample of the mutations that have transpired. Because of this, when variety is comfortable, biases while in the designs of substitutions noticed involving genomes will greater approximate mutational biases.  4d).